What is Levodopa? Can it help with stroke rehab? L-Dopa 可以幫助腦中風復健嗎?

L-Dopa 可以幫助腦中風復健嗎?

http://www.rehabafterstroke.com/levodopa-stroke-recovery

What is Levodopa? Can it help with stroke rehab?

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Levodopa, or L-Dopa, is the precursor of the chemical dopamine.  Dopamine is an important neurotransmitter in the brain, which has many functions, including some control of movement.  In fact, the inadequate production of dopamine is thought to cause the movement difficulties in people with Parkinson’s disease.  Therefore, administration of L-Dopa is a fairly common and effective treatment for improving the movement of Parkinson’s patients.

Below I’ve listed several studies that have investigated the use of L-dopa to enhance stroke recovery.  It seems promising!  And L-dopa is available in many forms, some of which are fairly easy to obtain.  (Such as herbal sources like Mucuna Pruriens, also known as the velvet bean.)  But there are possible side effects of L-Dopa, so don’t order a year’s supply of velvet bean just yet!  Ask your doctor about this potential treatment!

Does It Work?

有沒有效呢?

Restorative Neuorology and Neuroscience in 2004 published a study that concluded “in view of its minimal side effects, L-dopa can be recommended in conjunction with exercise therapy to improve the functional outcome in stroke rehabilitation.”
考量Levodopa很小的副作用,推薦腦中風使用Levodopa加強復健效果。
In 2009, Resotrative Neurology and Neuroscience published another small study, which compared 10 stroke survivors taking L-dopa to 10 on placebo.  They concluded that “a 5-week course of oral L-DOPA in a single daily dose substantially improves motor performance in patients with chronic stroke.”  All of the participants in this study were 10-48 months after their stroke, and the effects measured were increased walking speed and improved manual dexterity.
5個禮拜每天服用一次增強運動能力,增加走路速度和手部靈巧。

In 2001, Lancet published a study that compared 3 weeks of treatment with Levodopa to a placebo group.  They found that “levodopa is well tolerated and, when given in combination with physiotherapy, enhances motor recovery in patients with hemiplegia. In view of its minimal side-effects, levodopa will be a possible add- on during stroke rehabilitation.”

病人對Levodopa沒有不好的反應,和物理治療一起做,增加半身麻痺的病人運動能力。
考量很低的副作用,Levodopa可作為復健的幫助品。

In 2008, The Archives of Physical Medicine and Rehabilitation published a small German study that analyzed the effects of 3 doses of L-dopa prior to one session of physical therapy vs physical therapy alone.  Their results showed a significant improvement in what they called “procedural motor learning” of the involved hand (improved reaction time and performance of new movements and tasks with the hand).

每次物理治療療程前給3份劑量的L-dopa,有明顯的身體學習反應進步。

The Journal of Neurological Science published a study in 2009 which compared 20 patients receiving L-dopa and speech therapy to 19 patients receiving a placebo and speech therapy.  The group receiving L-dopa “experienced greater language improvement in verbal fluency and repetition, compared to the placebo group.”

比較20位接受L-Dopa和19位接受安慰劑治療,接受語言治療的效果。
接受L-Dopa的一組和安慰劑組相較,經歷更大的字句流暢度和重複進步。

Here’s an interesting blog about written by somebody with personal experience with the use of L-dopa for stroke recovery:

Bottom-Line:

The studies on Levodopa suggest that it could be helpful in stroke recovery, both motor recovery and speech improvement.  There are possible side-effects, so ask your doctor if this treatment might be worth trying.

總結:
研究證實Levodopa對於腦中風後復健有幫助,特別是身體反應和語言的進步。
有可能有副作用,所以要使用前請問你的醫生該不該做。

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